In the Baptism of Constantine the emperor kneels to receive the sacrament from Pope Sylvester inside the Baptistery of the Lateran. The pontiff has the traits of Clement VII (pontiff from 1523 to 1534), during whose pontificate work on the room was resumed, after its interruption during the brief interval of Hadrian VI (pontiff from 1521 to 1523), and the last two stories were painted. The fresco is attributed to Giovan Francesco Penni.
